Clinical Chemistry Blog Notes 40F: Hulyo 2012

Adults can distinguish between reality and fantasy, so such cartoon cannot affect us badly. Most of us have more interest to watch the cartoon picture and movies because of the creativity and fun, sometimes it is the best thing to be relaxed ourselves. But did you know that some of our favorite cartoon characters taking toxic drugs like:

Shaggy and Scooby Doo - Marijuana

420-Marijuana-Timothy-Teruo-Watters-Scooby-Doo-Where-Are-You-Art-Law-Officer

Popeye - Steroid

Droopy Dog - Barbiturates

The Roadrunner - Cocaine

Pictures Reference:
http://guyism.com/lifestyle/10-childrens-characters-who-were-definitely-on-drugs.html
http://www.cracked.com/funny-2842-beloved-cartoon-characters-drugs-they-probably-used/

WHAT is TOXICOLOGY?

Study of how natural or man - made poison caused undesirable effects in living organisms
Study of the adverse effects of chemical, physical or biological agents including the prevention of such adverse effects
Deals with the way chemicals and waste products affect the health of an individual
Is an essential development process of new drugs in the pharmaceutical industry

TERMS to TOXiC CHEMICALS

Poison - any substance that when ingested or injected within the body in small amount may, by its chemical action it can cause death or injury.
Toxicant - to denote any chemical that can potentially produce harm.

Toxin - chemicals that are produced by a living organism
Toxicity - degree to which a substance is poisonous.
Dose - actual amount of a chemical that enter's the body.
Xenobiotic - foreign to the body and any chemical that is not a natural component of the body. Any synthetic chemical that has NO beneficial in the body.

APPLiCATiON OF TOXiCOLOGY

Mechanistic Toxicology - make observations on how toxic substances cause their effect. Assessed the degree of exposure of poisoned individuals.

http://www.item.fraunhofer.de/en/business-fields/drug-research.html

Descriptive Toxicology - concerned with gathering toxicological information from animal experimentation.

http://www.davesblogcentral.com/2009/02/don-get-froggy-with-these-guys-if-you.html

Forensic Toxicology - concerned with medicolegal consequences of toxin exposure. Validating the analytical performance of the method used to generate evidence in legal situations.

http://www.sciencephoto.com/media/200891/enlarge

Clinical Toxicology - concerned with illness and diseases associated with short or long term exposure to toxic chemicals

http://www.holisticpharmd.com/2012/04/01/are-toxic-metals-inside-you/

Environmental Toxicology - concerned with the chemicals that contaminated and toxic substances that enter bodies of water.

http://www.tuberose.com/Environmental_Toxicity.html

Industrial Toxicology - concerned with health effects from exposure to chemicals in the workplace.

https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhnQ1PezcOZFB6zazgqx378Cc4Ai9co6yK5PhK4JN12WiAUawMZIxMwspYx7-eOLi7xwa8p6Qg9nuEvICdiIobwIl_UaGCwkDlvSjxzGM60IZidNJbQer6MmEB59L03O7f8ige4yhAF2YM/s1600/environmental-toxins.jpg

Food Toxicology - concerned with delivering a safe supply of food to the consumer.

http://5election.com/2010/12/17/the-toxic-food/

ROUTES OF EXPOSURE

Absorption - chemicals can cross the skin barrier and be absorbed into the blood stream

Inhalation - chemicals are either exhaled or deposited in the respiratory tract. Chemicals form of gases, mists, particulates and vapors.

Ingestion -chemicals that get into the mouth.

Injection - skin is punctured by contaminated objects

DURATiON OF EXPOSURE

Acute Exposure - application of a single or short term (generally less than a day) dosing by a chemical

Chronic Exposure - continuous exposure to a toxin often measured in months

TOXiC EFFECT

Mutagenicity - detection of possible ability to induce genetic alteration (mutation)

Teratogenicity - any substance capable of causing malformation during the development of the fetus.

(left)http://pgqb.blogspot.com/2012/01/teratogenic-drugs.html and (right)http://www.chm.bris.ac.uk/motm/thalidomide/first.html

Carcinogenicity - detection of possible ability to induce abnormal clonal uncontrolled proliferation of genetically altered cells.

(left)http://freeimagesarchive.com/img15358.search.htm,(right) http://sundds.wordpress.com/2009/03/28/smoking-drinking-your-teeth-away/

TOXiCODYNAMiC what poisons may do to the body. Molecular, biochemical and physiological of toxicants or their metabolites in biological systems.

TOXiCOKINETiCS is the quantitation of the time course of toxicants in the body or clearance of toxicants. A reflection of how the body handles toxicants as indicated by the plasma concentration of xenobiotic at various time points.